|β-Glucosidase Chemiluminescent Substrates|
|2L to 100L|
|Sβ-Glu101 - beta-D-glucosidase Substrate in Buffer||beta-Glucosidase enzyme, Reporter gene assays|
|Sβ-Glu102 - beta-D-glucosidase Substrate in Buffer Plus||beta-Glucosidase enzyme, Reporter gene assays|
Chemiluminescent Substrate for β-Glucosidase Enzyme
ß-Glucosidase Enzyme is present in nearly all species. It is reported that people with Gaucher’s disease have ß-Glucosidase gene mutations, which results in abnormal lysosomal storage.
Our new series of ultra-sensitive 1, 2-dioxetanes can detect ß- Glucosidase enzyme at very low level. MDPvt.Ltdchemiluminescent system is at least 1000 times more sensitive compared to the chromophoric substrates. These novel 1, 2-dioxetanes are protected by US Patent 6,461,876B1and other pending PCT and US patent applications.
MDPvt.Ltdsubstrates for ß-Glucosidase enzyme are more sensitive due to the effect of p-electrons on the decomposition of 1, 2-dioxetanes intermediate in the form of phenoxide ion formed after the interaction of glucoside group on 1, 2-dioxetane and ß-Glucosidase enzyme and can be shown as: